tatCD [2017-8-11 16:0:3]

component of the TatAD-TatCD twin-arginine translocase

locus: BSU02640

pI: 9.34

mw: 27.96 kDa

protein length: 245 aa

gene length: 735 bp

function: TAT protein secretion

product: component of the twin-arginine translocation pathway

essential: no

synonyms: ycbT

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.3|Phosphate metabolism]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 286,048 → 286,776

The protein

Catalyzed reaction/ biological activity

• translocation of [protein|597771E2E8EC31ED9B2CC8C0E4D888DEEA80F689|PhoD] [Pubmed|19395490]

Protein family

• tatC family (according to Swiss-Prot)

[SW|Localization]

• cell membrane [Pubmed|19616508]

Expression and Regulation

Operons

• genes: [gene|597771E2E8EC31ED9B2CC8C0E4D888DEEA80F689|phoD]-[gene|E4395255CD43ACB611E0BA872182DF801662C366|tatAD]-[gene|A58C9B9BB6574662A44AF0C7A94DFFE368B740E2|tatCD]
  description: [Pubmed|22383849]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|10094677], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP]: activation, [Pubmed|10094677,11007775], in [regulon|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP regulon]

  regulation

  • expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|10094677]

  additional information

  • expression of the operon depends on functional [protein|search|HemAT] and [protein|search|CsbC] [PubMed|23180473]

Biological materials

Mutant

• MGNA-C038 (ycbT::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2036 NBRP B. subtilis, Japan]

Labs working on this gene/protein

• [SW|Oscar Kuipers], University of Groningen, The Netherlands
• [http://molgen.biol.rug.nl/molgen/index.php Homepage]

References

Reviews

• 22683878,24140208,25975269,25494301,27121927

Original publications

• 11007775,15554971,22544248,11007775,19383693,19395490,19616508,22383849,10094677,23180473,24236045,27984091