D-alanine-D-alanine ligase
function
peptidoglycan precursor biosynthesis
product
D-alanine-D-alanine ligase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|SigM regulon]Gene
Coordinates on the chromosome (coding sequence)
508,248 -> 509,312
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP 2 D-alanine = ADP phosphate D-alanyl-D-alanine (according to Swiss-Prot) Protein family
ATP-grasp domain (according to Swiss-Prot)Structure
[PDB|2YZG] (from ''Thermus thermophilus hb8 mutant'', 40% identity, 53% similarity)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[SW|ddl]-[SW|murF]'' [Pubmed|22383849][SW|Sigma factor]
[protein|search|SigM] [Pubmed|18179421]Regulation
expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]References
