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mpr [Wed Jun 15 2016 16:35:15 GMT+0200 (CEST)]
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mpr [Wed Jun 15 2016 16:35:15 GMT+0200 (CEST)]

extracellular metalloprotease
locus
BSU02240
pI
8.00
mw
33.00 kDa
function
protein degradation
product
extracellular metalloprotease
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.5|Utilization of proteins]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.2|Extracellular feeding proteases]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|utilization of nitrogen sources other than amino acids], [SW|proteolysis]
  • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    245,190 -> 246,131

    The protein

    Protein family

  • peptidase S1B family (according to Swiss-Prot)
  • [SW|Localization]

  • extracellular (signal peptide) [Pubmed|18957862]
  • Expression and Regulation

    Operon

  • ''[protein|search|mpr]-[protein|search|ybfJ]'' [Pubmed|12107147]
  • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|25666135]
  • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [Pubmed|25666135]
  • Biological materials

    Mutant

  • BKE02240 (''ΔaprE::erm trpC2''), available at BGSC
  • KO7 (''ΔnprE ΔaprE Δepr Δmpr ΔnprB Δvpr Δbpr''), available as BGSC 1A1133
  • References

    Reviews

  • 20735481
  • Original publications

  • 15375126,24115457,18957862,12107147,25666135