SubtiBank SubtiBank
zur
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zur

transcriptional repressor, regulates zinc homeostasis
Locus
BSU_25100
Isoelectric point
4.86
Molecular weight
16.42 kDa
Protein length
145 aa Sequence Blast
Gene length
438 bp Sequence Blast
Function
regulation of zinc homeostasis(zagA, znuA-znuC-znuB)
Product
transcriptional repressor (Fur family)
Essential
no
Synonyms
yqfV

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
2,591,428 2,591,865

The protein

Protein family

  • Fur family (according to UniProt)
  • Paralogous protein(s)

    Modification

  • phosphorylated on ser/ thr/ tyr PubMed
  • Effectors of protein activity

  • sequential binding of zinc (two atoms per monomer) results in the activation of Zur dimer and thus in repression of the genes of the Zur regulon PubMed
  • zinc binding is negatively co-operative resulting in step-wise induction of the genes of the Zur regulon upon zinc depletion PubMed
  • Structure

  • 2FE3 (PerR, 35% identity) PubMed
  • Localization

  • information on binding sites can be found in the PRODORIC2 database
  • Expression and Regulation

    Operons

    Biological materials

    Mutant

  • 1A904 ( zur::spec), PubMed, available at BGSC
  • BKE25100 (zur::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGAAGGGTCCCCCTTTTC, downstream forward: _UP4_TAAAATGCGTATATATGAAA
  • BKK25100 (zur::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGAAGGGTCCCCCTTTTC, downstream forward: _UP4_TAAAATGCGTATATATGAAA
  • Labs working on this gene/protein

  • John Helmann, Cornell University, USA Homepage
  • References

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