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bmrR [Mon Aug 31 2015 13:55:29 GMT+0200 (CEST)]
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bmrR [Mon Aug 31 2015 13:55:29 GMT+0200 (CEST)]

general stress protein, transcriptional activator (MerR family) of the bmr-bmrR operon
locus
BSU24020
pI
5.19
mw
32.00 kDa
function
regulation of multidrug resistance
product
transcriptional activator (MerR family)
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]

    • [SW|Categories] containing this gene/protein

  • [SW|transcription factors and their control], [SW|general stress proteins (controlled by SigB)], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|BmrR regulon], [SW|Mta regulon], [SW|SigB regulon]

    • The protein

    Protein family

  • [SW|MerR family]

    • Structure

  • [PDB|2BOW] (complex with effector), [PDB|1R8E] (complex with DNA), [PDB|1BOW]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|bmrU]-[protein|search|bmr]-[protein|search|bmrR]'' [Pubmed|10220166]
  • ''[protein|search|bmr]-[protein|search|bmrR]'' [Pubmed|7961792]

    • [SW|Sigma factor]

  • ''[protein|search|bmrU]'': [protein|search|SigB] [Pubmed|11544224]
  • ''[protein|search|bmr]'': [protein|search|SigA] [Pubmed|10200972]

    • Regulation

  • ''[protein|search|bmrU]'': induced by stress ([protein|search|SigB]) [Pubmed|11544224]
  • ''[protein|search|bmr]'': induced by rhodamine 6G and tetraphenylphosphonium ([protein|search|BmrR]) [Pubmed|7961792]

    • Regulatory mechanism

  • [protein|search|BmrR]: transcription activation [Pubmed|7961792]
  • [protein|search|Mta]: transcription activation [Pubmed|10200972]

    • Labs working on this gene/protein

  • [SW|Richard Brennan], Houston, Texas, USA [http://www.mdanderson.org/departments/biochem/display.cfm?id=556ef368-6c81-4043-b74f350d41dd06cb&method=displayfull&pn=a8427ebd-d0ff-11d4-80fd00508b603a14 Homepage]

    • References

  • 7608059,10220166,11544224,7961792,10200972,20230832,21690368