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bmrR
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bmrR

general stress protein, transcriptional activator ([SW|MerR family]) of the [gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]-[gene|search|bmrR ]operon
locus
BSU_24020
pI
5.19
mw
32.43 kDa
protein length
278 aa Sequence Blast
gene length
837 bp Sequence Blast
function
regulation of multidrug resistance
product
transcriptional activator ([SW|MerR family])
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]

    • Gene

    Coordinates
    2,495,898 2,496,734

    The protein

    Protein family

  • [SW|MerR family]

    • [SW|Domains]

  • [SW|HTH merR-type domain] (aa 5-75) (according to UniProt)

    • Structure

  • [PDB|2BOW] (complex with effector), [PDB|1R8E] (complex with DNA), [PDB|1BOW]

    • Expression and Regulation

    Operons

    genes
    [gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]-[gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]
    description
    [Pubmed|7961792]

    sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|11544224], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]
  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|10200972], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|BmrR]: activation, [Pubmed|7961792], in [regulon|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|BmrR regulon]
  • [protein|A7326377132C670B60695EFE0A652B1E4F623698|Mta]: activation, [Pubmed|10200972], in [regulon|A7326377132C670B60695EFE0A652B1E4F623698|Mta regulon]

    • regulation

  • ''[protein|search|bmrU]'': induced by stress ([protein|search|SigB]) [Pubmed|11544224]
    • view in new tab

    genes
    [gene|88AECCE90DC0D6C92C61AB8860A31A830A8DAC42|bmrU]-[gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]-[gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]
    description
    [Pubmed|10220166]

    sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|11544224], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

    • regulation

  • ''[protein|search|bmrU]'': induced by stress ([protein|search|SigB]) [Pubmed|11544224]
    • view in new tab

    Biological materials

    Mutant

  • BKE24020 ([gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE24020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCCATCACTCCTTCTAT, downstream forward: _UP4_TAATAAAGCATAGAAAAAGA
  • BKK24020 ([gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK24020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCCATCACTCCTTCTAT, downstream forward: _UP4_TAATAAAGCATAGAAAAAGA

    • labs

  • [SW|Richard Brennan], Houston, Texas, USA [http://www.mdanderson.org/departments/biochem/display.cfm?id=556ef368-6c81-4043-b74f350d41dd06cb&method=displayfull&pn=a8427ebd-d0ff-11d4-80fd00508b603a14 Homepage]

    • References

  • 7608059,10220166,11544224,7961792,10200972,20230832,21690368