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hypO [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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hypO [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

NAD(P)H-flavin nitroreductase
locus
BSU07830
pI
5.00
mw
25.00 kDa
function
protection against NaOCl stress
product
NAD(P)H-flavin nitroreductase
essential
no
synonyms
yfkO
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.4|Electron transport/ other/ based on similarity]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

    • [SW|Categories] containing this gene/protein

  • [SW|electron transport/ other], [SW|resistance against oxidative and electrophile stress]

    • This gene is a member of the following [SW|regulons]

  • [SW|HypR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    854,412 -> 855,077

    Phenotypes of a mutant

  • a ''[protein|search|hypO] [protein|search|ohrA]'' mutant is more sensitive to NaOCl stress than ''[protein|search|ohrA]'' single mutant [Pubmed|22238377]

    • The protein

    Protein family

  • nitroreductase family (according to Swiss-Prot)

    • [SW|Cofactors]

  • FMN or FAD [Pubmed|21635694]

    • Expression and Regulation

    Operon

  • ''hypO'' [Pubmed|22238377]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|22238377]

    • Regulation

  • induced under disulfide stress conditions (diamide, NaOCl) ([protein|search|HypR]) [Pubmed|22238377]

    • Regulatory mechanism

  • [protein|search|HypR]:transcription activation [Pubmed|22238377]

    • Labs working on this gene/protein

  • [SW|Haike Antelmann], University of Greifswald, Germany

    • References

    Original articles

  • 20727918