SAVE THE DATE!
21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.
categories[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 220.127.116.11|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
Phenotypes of a mutantessential [Pubmed|12682299]
Catalyzed reaction/ biological activityATP + L-isoleucine + tRNAIle --> AMP + diphosphate + L-isoleucyl-tRNAIle (according to UniProt)
Protein family[SW|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)
Structure[PDB|1QU2] (from ''Staphylococcus aureus'', 61% identity) [Pubmed|10446055]
[SW|Localization]cytoplasm (according to Swiss-Prot)
Additional informationsubject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]
Expression and Regulation
regulatory mechanism[regulon|T-box|T-box]: antitermination, [pubmed|19258532], in [regulon|T-box|T-box]
regulationinduced by isoleucine limitation ([SW|T-box]) [Pubmed|19258532]the [SW|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]view in new tab