coaX [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

type III pantothenate kinase

locus: BSU00700

pI: 8.37

mw: 26.00 kDa

function: biosynthesis of coenzyme A

product: pantothenate kinase

essential: no

ec: 2.7.1.33

synonyms: yacB

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.4|Biosynthesis of coenzyme A]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)]

This gene is a member of the following [SW|regulons]

• [SW|SigM regulon]

Gene

Coordinates on the chromosome (coding sequence): 79,092 -> 79,868

The protein

Catalyzed reaction/ biological activity

• ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate (according to Swiss-Prot)

Protein family

• type III pantothenate kinase family (according to Swiss-Prot)

Structure

• [PDB|2H3G] (from ''Bacillus anthracis str. ames'', 75% identity, 88% similarity) [Pubmed|17323930]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|coaX]-[protein|search|yacC]'' [Pubmed|18179421]

[SW|Sigma factor]

• [protein|search|SigM] [Pubmed|18179421]

References

• 15795230,18179421,24784177