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thiM
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thiM

hydroxyethylthiazole kinase
Locus
BSU_38300
Isoelectric point
5.39
Molecular weight
28.06 kDa
Protein length
272 aa Sequence Blast
Gene length
819 bp Sequence Blast
Function
biosynthesis of thiamine
Product
hydroxyethylthiazole kinase
Essential
no
E.C.
2.7.1.50
Synonyms
thiK,ipa-25d,ywbJ
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis/ acquisition of thiamine

    • Gene

    Coordinates
    3,931,372 3,932,190

    The protein

    Catalyzed reaction/ biological activity

  • 5-(2-hydroxyethyl)-4-methylthiazole + ATP --> 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H+ (according to UniProt)

    • Protein family

  • Thz kinase family (single member, according to UniProt)

    • Structure

  • 1C3Q

    • Expression and Regulation

    Operons

    Genes
    ywbI-thiM-thiE
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
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    Biological materials

    Mutant

  • BKE38300 (thiM::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATTTGCATCATCCTTTA, downstream forward: _UP4_TCATGACTCGTATTTCTCGG
  • BKK38300 (thiM::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATTTGCATCATCCTTTA, downstream forward: _UP4_TCATGACTCGTATTTCTCGG

    • References

    Reviews

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    Original publications

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