SubtiBank SubtiBank
liaS [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

liaS [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

two-component sensor kinase/phosphatase, response to bacitracin
locus
BSU33090
pI
7.00
mw
40.00 kDa
function
control of LiaR activity in response to bacitracin
product
two-component sensor kinase
essential
no
synonyms
yvqE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

    • [SW|Categories] containing this gene/protein

  • [SW|protein modification], [SW|transcription factors and their control], [SW|resistance against oxidative and electrophile stress], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|LiaR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,395,035 -> 3,396,117

    The protein

    Catalyzed reaction/ biological activity

  • autophosphorylation, phosphorylation of [protein|search|LiaR]
  • dephosphorylation of [protein|search|LiaR] in the absence of the stress signal [Pubmed|23279150]

    • [SW|Domains]

  • two transmembrane segments, C-terminal histidine phosphotransferase domain

    • Modification

  • autophosphorylation on a His residue

    • Effectors of protein activity

  • LiaS kinase activity is inhibited by [protein|search|LiaF], phosphatase acitivity is maintained by [protein|search|LiaF] in the absence of the stress signal [Pubmed|23279150]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • [SW|Interactions]

  • [protein|search|LiaS]-[protein|search|LiaR]

    • Expression and Regulation

    Operon

  • ''[protein|search|liaI]-[protein|search|liaH]-[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|14651641]
  • ''[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|16816187]

    • [SW|Sigma factor]

  • ''liaI'': [protein|search|SigA] [Pubmed|15273097]
  • ''liaG'': [protein|search|SigA] [Pubmed|16816187]

    • Regulation

  • ''[protein|search|liaI]'': induced by bacitracin and rhamnolipids ([protein|search|LiaR]) [Pubmed|16816187,22092710]
  • ''[protein|search|liaI]'': repressed during logarithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed], indirect regulation by [protein|search|AbrB] [Pubmed|20817675]
  • ''[protein|search|liaG]'': constitutive

    • Regulatory mechanism

  • [protein|search|LiaR]: transcription activation [Pubmed|16816187]

    • Labs working on this gene/protein

  • [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

    • References

    Reviews

  • 27344142

    • Original publications

  • 18394148,19164152,15273097,17921301,10094672,19164157,14651641,17600057,17660417,16816187,15101989,17660417,20057163,23279150,20817675,22964256,22092710,23326432,27856233