SubtiBank SubtiBank
ycnK [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]
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ycnK [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

copper-responsive transcription repressor of the ycnK-ycnJ-ycnI operon
locus
BSU03960
pI
7.37
mw
21.00 kDa
function
regulation of copper uptake
product
transcription repressor, DeoR family
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.1|Copper]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [SW|Categories] containing this gene/protein

  • [SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|transcription factors and their control]
  • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|YcnK regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    448,461 -> 449,033

    Phenotypes of a mutant

  • elevated expression of ''[protein|search|ycnJ]'' under conditions of copper excess [Pubmed|19168619]
  • The protein

    Catalyzed reaction/ biological activity

  • repression of ''[protein|search|ycnK]-[protein|search|ycnJ]-[protein|search|ycnI]'' expression in the presence of excess copper [Pubmed|22904286,19168619]
  • Protein family

  • DeoR family of transcription factors
  • [SW|Cofactors]

  • copper acts as corepressor [Pubmed|19168619]
  • [SW|Interactions]

  • forms dimers [Pubmed|22904286]
  • Expression and Regulation

    Operon

  • ''[protein|search|ycnK]-[protein|search|ycnJ]-[protein|search|ycnI]'' [Pubmed|22904286,22383849]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|22904286]
  • Regulation

  • repressed during logrithmic growth ([protein|search|AbrB]) [Pubmed|15101989]
  • induced by copper limitation ([protein|search|YcnK]) [Pubmed|22904286]
  • induction of the ''[protein|search|ycnK]-[protein|search|ycnJ]-[protein|search|ycnI]'' in a ''[protein|search|csoR]'' mutant results from intracellular copper depletion due to the constitutive expression of the ''[protein|search|copZ]-[protein|search|copA]'' operon (copper export) [Pubmed|22904286]
  • Regulatory mechanism

  • [protein|search|AbrB]: transcription repression [Pubmed|15101989]
  • [protein|search|YcnK]: transcription repression [Pubmed|22904286]
  • Labs working on this gene/protein

  • [SW|Mohamed Marahiel], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage]
  • References

    Reviews

  • 22918892,25209494
  • Original publications

  • 19168619,22904286,22383849,15101989