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psdR [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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psdR [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

two-component response regulator (OmpR family), induction of psdA-psdB in response to lipid II-binding lantibiotics (nisin and gallidermin) and internal antimicrobial peptides (SdpC, SkfA)
locus
BSU34720
pI
4.00
mw
27.00 kDa
function
resistance against toxic peptides
product
two-component response regulator (OmpR family)
essential
no
synonyms
yvcP

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]
  • [SW|Categories] containing this gene/protein

  • [SW|transcription factors and their control], [SW|resistance against toxins/ antibiotics], [SW|phosphoproteins]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,567,422 -> 3,568,135

    The protein

    Protein family

  • [SW|OmpR family] of two-component response regulators
  • Modification

  • phosphorylated by [protein|search|PsdS] on an Asp residue
  • Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • [SW|Interactions]

  • [protein|search|PsdR]-[protein|search|PsdS]
  • Expression and Regulation

    Operon

  • ''[protein|search|psdR]-[protein|search|psdS]-[protein|search|psdA]-[protein|search|psdB]'' [Pubmed|21078927]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|21078927]
  • Biological materials

    Mutant

  • MGNA-B637 (yvcP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1636 NBRP B. subtilis, Japan]
  • References

  • 10094672,18394148,14651641,21283517,23504016,21078927,26364265,27188294