two-component response regulator (OmpR family), induction of psdA-psdB in response to lipid II-binding lantibiotics (nisin and gallidermin) and internal antimicrobial peptides (SdpC, SkfA)
function
resistance against toxic peptides
product
two-component response regulator (OmpR family)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue][SW|Categories] containing this gene/protein
[SW|transcription factors and their control], [SW|resistance against toxins/ antibiotics], [SW|phosphoproteins]Gene
Coordinates on the chromosome (coding sequence)
3,567,422 -> 3,568,135
The protein
Protein family
[SW|OmpR family] of two-component response regulatorsModification
phosphorylated by [protein|search|PsdS] on an Asp residueEffectors of protein activity
phosphorylation likely affects DNA-binding activity[SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|PsdR]-[protein|search|PsdS]Expression and Regulation
Operon
''[protein|search|psdR]-[protein|search|psdS]-[protein|search|psdA]-[protein|search|psdB]'' [Pubmed|21078927][SW|Sigma factor]
[protein|search|SigA] [Pubmed|21078927]Biological materials
Mutant
MGNA-B637 (yvcP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1636 NBRP B. subtilis, Japan]References
10094672,18394148,14651641,21283517,23504016,21078927,26364265,27188294