SubtiBank SubtiBank
resC [Mon Aug 31 2015 13:55:22 GMT+0200 (CEST)]
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resC [Mon Aug 31 2015 13:55:22 GMT+0200 (CEST)]

part of heam translocase, required for cytochrome c synthesis
locus
BSU23130
pI
9.00
mw
39.00 kDa
function
cytochrome c biogenesis
product
part of the ResB-ResC haem translocase
essential
yes
synonyms
ypxC

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.4|Respiration/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|respiration], [SW|essential genes], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|PhoP regulon], [SW|ResD regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,417,984 -> 2,419,159

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • haem-binding protein, translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane [Pubmed|19682263]
  • Protein family

  • ccmF/cycK/ccl1/nrfE/ccsA family (according to Swiss-Prot)
  • [SW|Localization]

  • cytoplasma membrane [Pubmed|19682263]
  • [SW|Interactions]

  • [protein|search|ResB]-[protein|search|ResC] [Pubmed|19682263]
  • Expression and Regulation

    [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8631715]
  • Regulation

  • expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
  • expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|9988472]
  • repressed by glucose ([protein|search|CcpA]) [Pubmed|16825793]
  • Regulatory mechanism

  • [protein|search|ResD]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
  • [protein|search|PhoP]: transcription activation [Pubmed|9988472]
  • [protein|search|CcpA]: transcription repression [Pubmed|16825793]
  • References

  • 10844653,19682263,8631715,11222591,9988472,17706591,16825793