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dctR
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dctR

two-component response regulator, regulation of the dctS-dctR-dctP operon
Locus
BSU_04460
Isoelectric point
8.60
Molecular weight
25.39 kDa
Protein length
226 aa Sequence Blast
Gene length
681 bp Sequence Blast
Function
regulation of the dctS-dctR-dctP operon
Product
two-component response regulator
Essential
no
Synonyms
ydbG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of organic acids
  • Information processing → Regulation of gene expression → Transcription factors and their control → Two-component system response regulators
  • Groups of genes → Phosphoproteins → Phosphorylation on an Asp residue

    • Gene

    Coordinates
    499,365 500,045

    The protein

    Domains

  • Response regulatory domain (aa 7-123) (according to UniProt)

    • Modification

  • phosphorylated by DctS on an Asp residue

    • Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity

    • Structure

  • 4HYE (Spr1814 from Streptococcus pneumoniae, 30% identity) PubMed

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    dctS-dctR-dctP
    Description
    PubMed

    Regulation

  • part of the iron sparing response, strong down-regulation in a fur mutant (Fur, FsrA) PubMed
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    Biological materials

    Mutant

  • BKE04460 (dctR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TTCAATGAGCAGAACCTTCC, downstream forward: _UP4_TAAACCTGAGACCAAAAAGA
  • BKK04460 (dctR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TTCAATGAGCAGAACCTTCC, downstream forward: _UP4_TAAACCTGAGACCAAAAAGA

    • References

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