SubtiBank SubtiBank
aroF [Mon Aug 31 2015 13:55:18 GMT+0200 (CEST)]
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aroF [Mon Aug 31 2015 13:55:18 GMT+0200 (CEST)]

chorismate synthase
locus
BSU22710
pI
6.00
mw
40.00 kDa
function
biosynthesis of aromatic amino acids
product
chorismate synthase
essential
no
ec
4.2.3.5
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids], [SW|phosphoproteins]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,379,100 -> 2,380,272

    The protein

    Catalyzed reaction/ biological activity

  • 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate phosphate (according to Swiss-Prot)
  • Protein family

  • acetokinase family (according to Swiss-Prot)
  • Modification

  • phosphorylated on Arg-127 [Pubmed|22517742]
  • Structure

  • [PDB|2O11] (from ''Mycobacterium tuberculosis h37rv mutant'', 42% identity, 58% similarity)
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|aroF]-[protein|search|aroB]-[protein|search|aroH]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])
  • ''[protein|search|aroF]-[protein|search|aroB]-[protein|search|aroH]-[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])
  • References

  • 4202998,22517742