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thiS [2019-06-27 14:25:26]
sulfur carrier protein, hydroxyethylthiazole phosphate biosynthesis
function
biosynthesis of thiamine
product
sulfur carrier protein
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]Gene
Coordinates
1,244,844 1,245,044
The protein
Structure
[PDB|1TYG] (complex with [protein|B58B8F260E446E28BC2E3A9AA84EA771EC0A8634|ThiG]) [Pubmed|15362849]Expression and Regulation
Operons
genes
[gene|47E47FB7D9C079DF603906694C4649A049814346|tenA]-[gene|CA6AAE8AC5B5EF01A911B035F8782579CD876C08|tenI]-[gene|87B5C84B7EE10F60B545CCFEF6A527A546B80432|thiO]-[gene|95DA3F899037140F48B99E065C768356CE08FA94|thiS]-[gene|B58B8F260E446E28BC2E3A9AA84EA771EC0A8634|thiG]-[gene|CCD3DDE9E52FCD4906735059CF30593BEB56FD1B|thiF]-[gene|97EDB4ACD64C5FA2E6014ED133DF18F602FF58BB|thiD]
description
[Pubmed|1898926]
regulatory mechanism
[protein|E195900D971AEE4A790D4579BE5E5A15B81010B8|Thi-box]: [SW|RNA switch], via [SW|RNA switch], in [regulon|E195900D971AEE4A790D4579BE5E5A15B81010B8|Thi-box regulon]regulation
repressed by thiamine ([SW|Thi-box]) [Pubmed|16356850]the [SW|Thi-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]view in new tabBiological materials
Mutant
BKE11680 ([gene|95DA3F899037140F48B99E065C768356CE08FA94|thiS]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE11680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTCTTTACCGTTCAGCTGTA, downstream forward: _UP4_ATTGTCCATTTTGTAGGAGGBKK11680 ([gene|95DA3F899037140F48B99E065C768356CE08FA94|thiS]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK11680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTCTTTACCGTTCAGCTGTA, downstream forward: _UP4_ATTGTCCATTTTGTAGGAGGReferences
Reviews
Original publications
