SubtiBank SubtiBank
argG [Mon May 16 2016 16:10:28 GMT+0200 (CEST)]
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argG [Mon May 16 2016 16:10:28 GMT+0200 (CEST)]

argininosuccinate synthase, reversible
locus
BSU29450
pI
5.00
mw
44.00 kDa
function
biosynthesis of arginine
product
argininosuccinate synthase, reversible
essential
no
ec
6.3.4.5
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids], [SW|phosphoproteins], [SW|most abundant proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|AhrC regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,013,133 -> 3,014,344

    The protein

    Catalyzed reaction/ biological activity

  • ATP L-citrulline L-aspartate = AMP diphosphate N(omega)-(L-arginino)succinate (according to Swiss-Prot)
  • Protein family

  • Type 1 subfamily (according to Swiss-Prot)
  • Modification

  • S-cysteinylation after diamide stress (C187) [Pubmed|17611193]
  • phosphorylated on Arg-262 [Pubmed|22517742]
  • Structure

  • [PDB|1KH1] (from ''Thermus thermophilus'', 44% identity, 65% similarity) [Pubmed|11844799]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|argG]-[protein|search|argH]'' [Pubmed|22383849]
  • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • repressed by arginine ([protein|search|AhrC])
  • Regulatory mechanism

  • [protein|search|AhrC]: transcription repression
  • Additional information

  • belongs to the 100 [[most abundant proteins]] [PubMed|15378759]
  • References

  • 17611193,22517742,12107147,22383849,15378759