SubtiBank SubtiBank
tsf
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tsf

elongation factor Ts
locus
BSU_16500
pI
4.00
mw
32.00 kDa
protein length
293 aa Sequence Blast
gene length
882 bp Sequence Blast
function
translation
product
elongation factor Ts
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.11|Translation factors]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
  • Gene

    Coordinates
    1,718,775 1,719,656

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Protein family

  • EF-Ts family (single member, according to UniProt)
  • Modification

  • phosphorylation on Ser-149 [Pubmed|17218307]
  • Structure

  • [PDB|1EFU] (from ''E. coli'', 50% identity) [Pubmed|8596629]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • additional information

  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
  • Expression and Regulation

    Operons

    genes
    [gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]-[gene|94E1130A787CBCCCDBDA93C8AFC24ECB82D5FE61|tsf]-[gene|40655595D0C573B4CB75FB255CBB01A6ACF1F94D|pyrH]-[gene|093960C48AD50C0D0B3A68BBFE7D060BE716935D|frr]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, [pubmed|11948165], in [regulon|stringent response|stringent response]
  • regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
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    References

  • 17218307,15378759,8596629,28516784