SubtiBank SubtiBank
tsf
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tsf

elongation factor Ts
locus
BSU16500
pI
4.00
mw
32.00 kDa
protein length
293 aa Sequence Blast
gene length
882 bp Sequence Blast
function
translation
product
elongation factor Ts
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.11|Translation factors]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
  • Gene

    Coordinates
    1,718,775 1,719,656

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Protein family

  • EF-Ts family (according to Swiss-Prot)
  • Modification

  • phosphorylation on Ser-149 [Pubmed|17218307]
  • Structure

  • [PDB|1EFU] (from ''E. coli'', 50% identity) [Pubmed|8596629]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • additional information

  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
  • Expression and Regulation

    Operons

    genes
    [gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]-[gene|94E1130A787CBCCCDBDA93C8AFC24ECB82D5FE61|tsf]-[gene|40655595D0C573B4CB75FB255CBB01A6ACF1F94D|pyrH]-[gene|093960C48AD50C0D0B3A68BBFE7D060BE716935D|frr]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, [pubmed|11948165], in [regulon|stringent response|stringent response]
  • regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
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    References

  • 17218307,15378759,8596629,28516784