function
myo-inositol catabolism
product
inositol 2-dehydrogenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.16|Utilization of inositol][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|IolR regulon]Gene
Coordinates on the chromosome (coding sequence)
4,075,785 -> 4,076,819
The protein
Catalyzed reaction/ biological activity
Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH (according to Swiss-Prot)Protein family
gfo/idh/mocA family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YfiI], [protein|search|NtdC], [protein|search|YrbE], [protein|search|YteT], [protein|search|YulF], [protein|search|IolW], [protein|search|IolX][SW|Cofactors]
NAD+ [Pubmed|20809899]Structure
[PDB|3MZ0] [Pubmed|20809899][SW|Interactions]
the protein forms a tetramer [Pubmed|20809899]Expression and Regulation
Operon
''[protein|search|iolA]-[protein|search|iolB]-[protein|search|iolC]-[protein|search|iolD]-[protein|search|iolE]-[protein|search|iolF]-[protein|search|iolG]-[protein|search|iolH]-[protein|search|iolI]-[protein|search|iolJ]'' [Pubmed|9226270][SW|Sigma factor]
[protein|search|SigA] [Pubmed|9226270]Regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|10666464]induced by inositol ([protein|search|IolR]) [Pubmed|9887260,9226270]Regulatory mechanism
[protein|search|IolR]: transcription repression [Pubmed|9887260,9226270][protein|search|CcpA]: transcription repression [Pubmed|10666464]Labs working on this gene/protein
[SW|Yasutaro Fujita], University of Fukuyama, Japan[[Ken-ichi Yoshida]], Kobe University, JapanReferences
9226270,6322857,1761221,112095,9887260,18310071,112095,20809899,23952058,24325193,25019153 
