proI [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

pyrroline-5-carboxylate reductase

locus: BSU23800

pI: 6.70

mw: 30.00 kDa

function: biosynthesis of proline

product: pyrroline-5-carboxylate reductase

essential: no

ec: 1.5.1.2

synonyms: yqjO

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.2|Biosynthesis/ acquisition of proline]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|T-box]

Gene

Coordinates on the chromosome (coding sequence): 2,473,151 -> 2,473,987

The protein

Catalyzed reaction/ biological activity

• L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H (according to Swiss-Prot)

Protein family

• pyrroline-5-carboxylate reductase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|ProH]

Expression and Regulation

Operon

• ''proI'' [Pubmed|21784929]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|21233158]

Regulation

• induced by proline limitation ([protein|search|T-box]) [Pubmed|21233158]

Regulatory mechanism

• [protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|21233158]

References

Reviews

• 25367752

Original publications

• 19258532,21233158,11418582,21784929