ribose-5-phosphate isomerase
function
pentose phosphate pathway
product
ribose-5-phosphate isomerase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.1|Carbon core metabolism] → [category|SW 2.2.1.3|Pentose phosphate pathway][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes][SW|Categories] containing this gene/protein
[SW|carbon core metabolism]This gene is a member of the following [SW|regulons]
[SW|TnrA regulon]Gene
Coordinates on the chromosome (coding sequence)
3,791,199 -> 3,791,648
The protein
Protein family
lacAB/rpiB family (according to Swiss-Prot)Kinetic information
Reversible Mass Action Kinetics [Pubmed|956158] [Pubmed|7144591]Effectors of protein activity
Inhibited by 6-phosphogluconate and AMP [Pubmed|7144591]Inhibited by divalent ions such as Ag2, Mg2, Co2 and Zn2 [Pubmed|956158]Activated by EDTA and 2-mercaptoethanol [Pubmed|7144591] Structure
[PDB|3HEE] (from ''Clostridium thermocellum'', 55% identity, 72% similarity)Additional information
The enzyme has probably more than one active site, but with no cooperativity described [Pubmed|7144591]Expression and Regulation
Operon
''[protein|search|ywlF]-[protein|search|ywlG]'' [Pubmed|12823818]Regulation
repressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [Pubmed|12823818]Regulatory mechanism
[protein|search|TnrA]: transcription repression [Pubmed|12823818]Biological materials
FLAG-tag construct
GP1404 (spc, based on [SW|pGP1331]), available in the [SW|Stülke] labAntibody
**References
25755103,12823818,19446032,956158,7144591,956158 
