SubtiBank SubtiBank
scpB [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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scpB [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

part of the condensin complex, chromosomal origin condensation and segregation
locus
BSU23210
pI
4.00
mw
21.00 kDa
function
segregation of replication origins
product
DNA segregation and condensation protein
essential
yes
synonyms
ypuH

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
  • [SW|Categories] containing this gene/protein

  • [SW|DNA condensation/ segregation], [SW|essential genes]
  • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,425,248 -> 2,425,841

    Phenotypes of a mutant

  • essential [Pubmed|24440399]
  • ''[protein|search|scpB]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth [Pubmed|24440399,24440393]
  • The protein

    Protein family

  • scpB family (according to Swiss-Prot)
  • Structure

  • [PDB|4I98] (complex between [protein|search|ScpA] (aa 1-160)-[protein|search|ScpB] (aa 1-183) [Pubmed|23353789]
  • [SW|Localization]

  • nucleoid (Multiple) [Pubmed|16479537]
  • the [SW|condensin] ([protein|search|Smc])2-[protein|search|ScpA]-[protein|search|ScpB] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [SW|Spo0J] [Pubmed|24440393,23475963]
  • [SW|Interactions]

  • part of the [SW|condensin] complex [Pubmed|24440399,24440393]
  • forms dimers [Pubmed|22385855]
  • [protein|search|ScpB]-[protein|search|Smc] [Pubmed|22385855,12100548], this interaction takes place only in the presence of [protein|search|ScpA] [Pubmed|22385855]
  • [protein|search|ScpA]-[protein|search|ScpB] [Pubmed|23353789,12100548]
  • Expression and Regulation

    Operon

  • ''[protein|search|scpA]-[protein|search|scpB]-[protein|search|ypuI]'' [Pubmed|7934830]
  • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • Biological materials

    Mutant

  • MGNA-A105 (ypuH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/105 NBRP B. subtilis, Japan]
  • References

    Reviews

  • 22933559,22934648,24118085,25460803,26706151
  • Original publications

  • 12100548,12065423,12421306,22385855,16479537,19450516,12897137,7934830,11948165,23353789,24440399,24440393,25071173,25557547,25951515,26253537,23475963,26295962,26725510,26904953