SubtiBank SubtiBank
tagB
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tagB

putative CDP-glycerol:glycerol phosphate glycerophosphotransferase
locus
BSU35760
pI
8.93
mw
44.40 kDa
protein length
381 aa Sequence Blast
gene length
1143 bp Sequence Blast
function
biosynthesis of teichoic acid
product
putative CDP-glycerol:glycerol phosphate glycerophosphotransferase
essential
yes
ec
2.7.8.-
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    3,682,173 → 3,683,318

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • adds a single glycerol phosphate residue to the non-reducing end of the undecaprenol-phosphate-linked N-acetylmannosamine-β(1,4)-N-acetylglucosamine-1-phosphate [Pubmed|17660278]
  • Protein family

  • CDP-glycerol glycerophosphotransferase family (according to Swiss-Prot)
  • [SW|Localization]

  • cell membrane [Pubmed|17660278]
  • Expression and Regulation

    Operons

    genes
    [gene|72A89412C53703F96F835D26307263F5D1A4AB4E|tagA]-[gene|911A4D957A6C0DFC636A152395119DBFC777DDA2|tagB]
    description
    [Pubmed|7952180]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|7581998], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP]: repression, [Pubmed|9457886], in [regulon|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP regulon]
  • [protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|WalR]: activation, [Pubmed|12950927], in [regulon|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|WalR regulon]
  • regulation

  • repressed when phosphate is available ([protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP]) [Pubmed|9457886]
  • the leader mRNA is processed upstream of [gene|72A89412C53703F96F835D26307263F5D1A4AB4E|tagA] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|YmcA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|YlbF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|YaaT] complex [Pubmed|29794222]
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    References

    Reviews

  • 24024634
  • Original publications

  • 18156271,9457886,17660278,7581998,16150696,7952180,12950927,15547257