ntdR

transcription activator of the ntdA-ntdB-ntdC-glcP operon

Locus: BSU_10560

Isoelectric point: 6.64

Molecular weight: 37.53 kDa

Protein length: 329 aa

Gene length: 990 bp

Function: regulation of the ntdA-ntdB-ntdC-glcP operon

Product: transcriptional regulator (LacI family)

Essential: no

Synonyms: yhjM

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Miscellaneous metabolic pathways → Biosynthesis of antibacterial compounds
• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other
• Lifestyles → Coping with stress → Biosynthesis of antibacterial compounds

Gene

Coordinates: 1,129,715 1,130,704

The protein

Catalyzed reaction/ biological activity

• transcription activation of the ntdA-ntdB-ntdC-glcP operon PubMed

Protein family

• LacI family

Domains

• HTH lacI-type domain (aa 2-56) (according to UniProt)

Structure

• 2HSG (ccpA from B. megaterium, 31% identity) PubMed

Expression and Regulation

Operons

• Genes: ntdR
  Description: PubMed

  Regulatory mechanism

  • AbrB: repression, PubMed, in AbrB regulon

Biological materials

Mutant

• MGNA-A726 (yhjM::erm), available at the NBRP B. subtilis, Japan
• BKE10560 (ntdR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATTTTCCCTTCCTTAAA, downstream forward: _UP4_TAACGATAGATTTCCCTTTA
• BKK10560 (ntdR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATTTTCCCTTCCTTAAA, downstream forward: _UP4_TAACGATAGATTTCCCTTTA

References

Reviews

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Original publications

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