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parC [Sun Nov 27 2016 18:15:57 GMT+0100 (CET)]
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parC [Sun Nov 27 2016 18:15:57 GMT+0100 (CET)]

subunit of DNA topoisomerase IV
locus
BSU18100
pI
6.00
mw
91.00 kDa
function
chromosome segregation and compaction
product
subunit of DNA topoisomerase IV
essential
yes
ec
5.99.1.-
synonyms
grlA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|DNA condensation/ segregation], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|LexA regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,935,448 -> 1,937,868

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Protein family

  • topoisomerase gyrA/parC subunit family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|GyrA]

    • Structure

  • [PDB|1WP5] (C-terminal domain, Geobacillus stearothermophilus)

    • [SW|Localization]

  • cytoplasm (Homogeneous) [Pubmed|16479537]
  • polar localization in actively growing cells [Pubmed|9539793]

    • [SW|Interactions]

  • [protein|search|ParC]-[protein|search|ParE] [Pubmed|9539793]

    • Expression and Regulation

    Operon

  • ''[protein|search|parE]-[protein|search|parC]'' [Pubmed|16267290]

    • Regulation

  • induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]

    • Regulatory mechanism

  • [protein|search|LexA]: transcription repression [Pubmed|16267290]

    • References

  • 16272394,15466871,16267290,16479537,9539793