SubtiBank SubtiBank
parC
Save the date! 20th International Conference on Bacilli and Gram-Positive Bacteria. Washington, D.C. July 23-26, 2019.

parC

subunit of DNA topoisomerase IV
locus
BSU_18100
pI
6.31
mw
91.14 kDa
protein length
806 aa Sequence Blast
gene length
2421 bp Sequence Blast
function
chromosome segregation and compaction
product
subunit of DNA topoisomerase IV
essential
yes
ec
5.99.1.-
synonyms
grlA

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    1,935,448 1,937,868

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • a ''parC'' point mutation has been isolated upon selction at low pressure [Pubmed|26296725]
  • upon overexpression, topoisomerase IV ([protein|1901C52DCB24B3D53150F6926C14907AC1B75293|ParE]-[protein|9075DD0CC0B8554F0379732453665F43C70EFC26|ParC]) can take over the functions of the type 1A topoisomerases [protein|41199C76DF8CA804B7B8878D61228B9542A96AE4|TopA] and [protein|7D5327BD1DD5FD5F90B2C849589923AA3D8B20EF|TopB] [pubmed|30957856]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to UniProt)
  • Protein family

  • Topoisomerase IIA [protein|B207C7328177924B16F1C606F667BEADF12CA069|GyrA]/[protein|9075DD0CC0B8554F0379732453665F43C70EFC26|ParC] subunit family (together with [protein|B207C7328177924B16F1C606F667BEADF12CA069|GyrA]) (according to UniProt)
  • Paralogous protein(s)

  • [protein|B207C7328177924B16F1C606F667BEADF12CA069|GyrA]
  • Structure

  • [PDB|1WP5] (C-terminal domain, Geobacillus stearothermophilus)
  • [SW|Localization]

  • cytoplasm (Homogeneous) [Pubmed|16479537]
  • polar localization in actively growing cells [Pubmed|9539793]
  • Expression and Regulation

    Operons

    genes
    [gene|1901C52DCB24B3D53150F6926C14907AC1B75293|parE]-[gene|9075DD0CC0B8554F0379732453665F43C70EFC26|parC]
    description
    [Pubmed|16267290]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [pubmed|30957856], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]: repression, [Pubmed|16267290], in [regulon|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA regulon]
  • regulation

  • induced by DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]) [Pubmed|16267290]
  • additional information

  • term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''parE'' [Pubmed|27120414]
  • view in new tab

    References

    Reviews

  • 16936698
  • Original publications

  • 16272394,15466871,16267290,16479537,9539793,26296725,12767818,10713132,9334322,8940171,7590259,109442141330320,12857958,11090135,8104339,8227000,30222737,30957856