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bioI [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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bioI [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

cytochrome P450 enzyme
locus
BSU30190
pI
6.20
mw
44.00 kDa
function
biosynthesis of biotin
product
cytochrome P450 enzyme
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.1|Biosynthesis/ acquisition of biotin]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]
  • This gene is a member of the following [SW|regulons]

  • [SW|BirA regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,089,226 -> 3,090,413

    The protein

    Catalyzed reaction/ biological activity

  • formation of pimelic acid via a multiple-step oxidative cleavage of long-chain fatty acids
  • Protein family

  • [SW|cytochrome P450] family (according to Swiss-Prot)
  • Structure

  • [PDB|3EJB], [PDB|3EJE] (complex with [protein|search|AcpA]) [Pubmed|18838690]
  • [SW|Interactions]

  • [protein|search|Fer]-[protein|search|BioI] [Pubmed|12538057]
  • [protein|search|YkuP]-[protein|search|BioI] [Pubmed|15449930]
  • [protein|search|AcpA]-[protein|search|BioI] [Pubmed|18838690]
  • Expression and Regulation

    Operon

  • ''[protein|search|bioW]-[protein|search|bioA]-[protein|search|bioF]-[protein|search|bioD]-[protein|search|bioB]-[protein|search|bioI]-[protein|search|ytbQ]'' [Pubmed|8763940,8892842]
  • Regulation

  • repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|8763940,8892842]
  • Regulatory mechanism

  • [protein|search|BirA]: transcription repression [Pubmed|8763940,8892842]
  • References

    Reviews
    [Pubmed|21437340]==

    Original publications

  • 18838690,8763940,8892842,15449931,15449930,12538057,20658980,11368323,11472016,14737344,12943422