thiE [Mon Aug 31 2015 13:57:28 GMT+0200 (CEST)]

thiamine-phosphate pyrophosphorylase

locus: BSU38290

pI: 5.06

mw: 23.00 kDa

function: biosynthesis of thiamine
by 4-methyl-5-(beta-hydroxyethyl)thiazole phosphate
to yield thiamine phosphate

product: thiamine-phosphate pyrophosphorylase

essential: no

ec: 2.5.1.3

synonyms: thiC, ipa-26d, ywbK

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]

syns: thiC, ipa-26d, ywbK

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

The protein

Catalyzed reaction/ biological activity

• 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate (according to Swiss-Prot)

Protein family

• TMP-PPase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|TenI]

Structure

• [PDB|1G6C]

Expression and Regulation

Operon

• ''[protein|search|ywbI]-[protein|search|thiM]-[protein|search|thiE]'' [Pubmed|9139923]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9139923]

References

Reviews

• 19348578

Original publications

• 9139923