acyl-acyl carrier protein (ACP):phosphate acyltransferase, catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4), coordinates membrane synthesis with cell division
function
biosynthesis of phospholipids
product
acyl-acyl carrier protein (ACP):phosphate acyltransferase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes][category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell division], [SW|biosynthesis of lipids], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|ComA regulon], [SW|FapR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,662,547 -> 1,663,548
Phenotypes of a mutant
essential [Pubmed|24224907,12682299]depletion results in sporulation deficiency (via [SW|SpoIIR]) [Pubmed|22111992]a ts mutant forms an abberant Z-ring and has a [SW|cell division] defect [Pubmed|24224907]The protein
Catalyzed reaction/ biological activity
catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)Protein family
plsX family (according to Swiss-Prot)Structure
[PDB|1VI1] [Pubmed|16021622][SW|Localization]
localizes to the cell division sites, colocalizes with the Z-ring [Pubmed|24224907]uniformly distributed on the membrane of most cells, but occasionally appears as membrane foci as well [Pubmed|26816052][SW|Interactions]
[protein|search|PlsX]-[protein|search|PlsY] [Pubmed|19282621][protein|search|PlsX]-[protein|search|FtsA] [Pubmed|24224907]Expression and Regulation
Operon
''[protein|search|fapR]-[protein|search|plsX]-[protein|search|fabD]-[protein|search|fabG]-[protein|search|acpA]'' [Pubmed|12737802,19850612][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16932747]Regulation
induced if the cells experience an accumulation of malonyl-CoA ([protein|search|FapR]) [Pubmed|12737802]expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]induced upon fatty acid biosynthesis inhibition [Pubmed|21383089]Regulatory mechanism
[protein|search|ComA]: transcription activation ([protein|search|ComA]) [Pubmed|16091051][protein|search|FapR]: transcription repression [Pubmed|12737802]Biological materials
two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in Matsumoto lab [Pubmed|19282621]References
12737802,19282621,17645809,17557823,8759840,16932747,19850612,16091051,21383089,22111992,24224907,26816052,16021622 
