component of the SpoIIIA-SpoIIQ trans-envelope complex, required for the activation of SigG
function
activation of SigG
product
component of the SpoIIIA-SpoIIQ trans-envelope complex
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.3|Sporulation/ other][SW|Categories] containing this gene/protein
[SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|SigF regulon], [SW|ComK regulon]Gene
Coordinates on the chromosome (coding sequence)
2,555,887 -> 2,556,066
Phenotype of a mutant
reduced sporulation efficiency (14% compared to wild type) [Pubmed|26735940]the ''[SW|spoIIIL] [SW|spoIIIAH]'' double mutant has a severe sporulation defect (0.001%) [Pubmed|26735940]The protein
[SW|Localization]
forespore [Pubmed|26735940]Expression and Regulation
Operon
''[SW|comGA]-[SW|comGB]-[SW|comGC]-[SW|comGD]-[SW|comGE]-[SW|comGF]-[SW|comGG]-[protein|search|spoIIIL]'' [Pubmed|26735940,2507524]''[SW|spoIIIL]'' [Pubmed|26735940][SW|Sigma factor]
''[SW|comGA]'': [protein|search|SigA] [Pubmed|2507524]''[SW|spoIIIL]'': [protein|search|SigF] [Pubmed|26735940]Regulation
repressed by casamino acids [Pubmed|12107147]strongly repressed in response to glucose starvation in M9 medium [Pubmed|23033921]expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|26735940]Regulatory mechanism
[protein|search|ComK]: transcription activation [Pubmed|8196543]Additional information
the ''[SW|comGA]-[SW|comGB]-[SW|comGC]-[SW|comGD]-[SW|comGE]-[SW|comGF]-[SW|comGG]-[protein|search|spoIIIL]'' operon requires [SW|NusA] for expression [http://www.nature.com/articles/nmicrobiol20157 Reference]References
2507524,23033921,12107147,8196543,26735940 
