alkyl hydroperoxide reductase (large subunit) / NADH dehydrogenase
function
resistance against peroxide stres
product
alkyl hydroperoxide reductase (large subunit) /
NADH dehydrogenase
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.7|Phosphorylation on a Tyr residue][SW|Categories] containing this gene/protein
[SW|resistance against oxidative and electrophile stress], [SW|membrane proteins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|PerR regulon]Gene
Coordinates on the chromosome (coding sequence)
4,119,527 -> 4,121,056
The protein
Catalyzed reaction/ biological activity
NADH acceptor = NAD reduced acceptor (according to Swiss-Prot) Protein family
class-II pyridine nucleotide-disulfide oxidoreductase family (according to Swiss-Prot)Modification
phosphorylation on (Ser-48 OR Ser-49) [Pubmed|17218307]phosphorylated on Arg-457 [Pubmed|22517742]Structure
[PDB|1HYU] (from ''Salmonella typhimurium'', 52% identity, 69% similarity) [Pubmed|11300769][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|ahpC]-[protein|search|ahpF]'' [Pubmed|8932314][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8932314]Regulation
induced by H2O2 ([protein|search|PerR]) [Pubmed|11532148]Regulatory mechanism
[protein|search|PerR]: transcription repression [Pubmed|11532148]References
11532148,16232966,8932314,8932315,11532148,17218307,22517742 
