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bceA [Sat Jan 21 2017 11:51:23 GMT+0100 (CET)]
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bceA [Sat Jan 21 2017 11:51:23 GMT+0100 (CET)]

primary bacitracin resistance determinant, ABC transporter (ATP-binding protein) for the export of bacitracin, plectasin, mersacidin and actagardine
locus
BSU30380
pI
9.00
mw
28.00 kDa
function
export of toxic peptides
product
bacitracin ABC transporter (ATP-binding protein)
essential
no
synonyms
ytsC

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.3|Export of peptides]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|BceR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,111,327 -> 3,112,088

    The protein

    Protein family

  • [SW|ABC transporter] family (according to Swiss-Prot)
  • Effectors of protein activity

  • the activity of the [protein|search|BceA]-[protein|search|BceB] [SW|ABC transporter] is inhibited by heptaprenyl pyrophosphate which accumulates in a ''[protein|search|ytpB]'' mutant [Pubmed|24806199]
  • Structure

  • [PDB|1L2T] (MJ0796 from '' Methanocaldococcus jannaschii '', 38% identity) [Pubmed|12150914]
  • [SW|Localization]

  • membrane associated (via [protein|search|BceB]) [Pubmed|12890034]
  • [SW|Interactions]

  • [protein|search|BceA]-[protein|search|BceB] [Pubmed|25118291,23687272]
  • Expression and Regulation

    Operon

  • ''[protein|search|bceA]-[protein|search|bceB]'' [Pubmed|12890034]
  • Regulation

  • induced in the presence of bacitracin, plectasin, mersacidin and actagardine ([protein|search|BceR]) [Pubmed|12890034]
  • strongly induced in the stationary phase due to the internal production of toxic peptides ([SW|SdpC], [SW|SkfA]) ([protein|search|BceR]) [Pubmed|26364265]
  • strong induction by [SW|SkfA], weaker induction by [SW|SdpC] [Pubmed|26364265]
  • Regulatory mechanism

  • [protein|search|BceR]: transcription activation [Pubmed|12890034]
  • Biological materials

    Mutant

  • MGNA-A167 (ytsC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/167 NBRP B. subtilis, Japan]
  • Labs working on this gene/protein

  • Foglino M. [Pubmed|17905982]
  • References

    Reviews

  • 27344142
  • Original publications

  • 17905982,18394148,12890034,14651641,10092453,14612242,21283517,20606066,21078927,23687272,24806199,25118291,26199330,26364265,12150914,27997719