SubtiBank SubtiBank
cwlT [Mon Aug 31 2015 13:52:38 GMT+0200 (CEST)]
Save the date! 20th International Conference on Bacilli and Gram-Positive Bacteria. Washington, D.C. July 23-26, 2019.

cwlT [Mon Aug 31 2015 13:52:38 GMT+0200 (CEST)]

cell wall hydrolase, required for conjugation of ICEBs1, part of the type IV secretion system for DNA transfer , C-terminal domain hydrolyzes bond between D-Glu and m-DAP
locus
BSU04970
pI
8.63
mw
36.00 kDa
function
conjugative transfer of ICEBs1
product
cell wall hydrolase
synonyms
yddH

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.1|Autolysis]
  • [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.2|Mobile genetic elements] → [category|SW 5.2.1|ICEBs1]
  • syns
    yddH

    [SW|Categories] containing this gene/protein

  • [SW|mobile genetic elements], [SW|cell wall degradation/ turnover]
  • The protein

    Catalyzed reaction/ biological activity

  • hydrolysis of peptidoglycan (linkage between N-acetylmuramic acid and N-acetylglucosamine and bond between D-γ-glutamate and meso-diaminopimelic acid) [Pubmed|18305117]
  • Protein family

  • nlpC/p60 family (according to Swiss-Prot)
  • [SW|Domains]

  • N-terminal domain is an N-acetylmuramidase that cleaves the linkage between N-acetylmuramic acid and N-acetylglucosamine [Pubmed|18305117]
  • C-terminal endopeptidase domain cleaves the bond between D-γ-glutamate and meso-diaminopimelic acid [Pubmed|18305117]
  • [SW|Localization]

  • secreted (with signal peptide) [Pubmed|24532767]
  • may be a lipoprotein, but the lipid anchor is not required for function [Pubmed|24532767]
  • Expression and Regulation

    Regulation

  • induced by mitomycin C [Pubmed|18305117]
  • References

  • 18305117,24532767