cell wall hydrolase, required for conjugation of ICEBs1, part of the type IV secretion system for DNA transfer , C-terminal domain hydrolyzes bond between D-Glu and m-DAP
function
conjugative transfer of ICEBs1
product
cell wall hydrolase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.1|Autolysis][category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.2|Mobile genetic elements] → [category|SW 5.2.1|ICEBs1][SW|Categories] containing this gene/protein
[SW|mobile genetic elements], [SW|cell wall degradation/ turnover]The protein
Catalyzed reaction/ biological activity
hydrolysis of peptidoglycan (linkage between N-acetylmuramic acid and N-acetylglucosamine and bond between D-γ-glutamate and meso-diaminopimelic acid) [Pubmed|18305117]Protein family
nlpC/p60 family (according to Swiss-Prot)[SW|Domains]
N-terminal domain is an N-acetylmuramidase that cleaves the linkage between N-acetylmuramic acid and N-acetylglucosamine [Pubmed|18305117]C-terminal endopeptidase domain cleaves the bond between D-γ-glutamate and meso-diaminopimelic acid [Pubmed|18305117][SW|Localization]
secreted (with signal peptide) [Pubmed|24532767]may be a lipoprotein, but the lipid anchor is not required for function [Pubmed|24532767]Expression and Regulation
Regulation
induced by mitomycin C [Pubmed|18305117]References
