function
salicin utilization
product
phospho-beta-glucosidase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.18|Utilization of beta-glucosides][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|LicT regulon]Gene
Coordinates on the chromosome (coding sequence)
4,032,346 -> 4,033,755
The protein
Catalyzed reaction/ biological activity
6-phospho-beta-D-glucosyl-(1,4)-D-glucose H2O = D-glucose D-glucose 6-phosphate (according to Swiss-Prot)Protein family
glycosyl hydrolase 1 family (according to Swiss-Prot)Structure
[PDB|4IPL] (from ''Streptococcus pneumoniae'', 60% identity)Expression and Regulation
Operon
''[protein|search|bglP]-[protein|search|bglH]-[protein|search|yxiE]'' [Pubmed|7883710][SW|Sigma factor]
[protein|search|SigA] [Pubmed|7559347]Regulation
repressed by glucose ([protein|search|CcpA], [protein|search|LicT]) [Pubmed|7559347]induced by salicin ([protein|search|LicT]) [Pubmed|7883710]Regulatory mechanism
[protein|search|CcpA]: transcription repression, ([protein|search|CcpA] binding site overlaps -35 region) [Pubmed|7559347][protein|search|LicT]-dependent [SW|RNA switch] (antitermination, lack of [protein|search|LicT]-dependent antitermination in the presence of gucose due to the requirement of [protein|search|LicT] to be phosphorylated by [PtsH|search| HPr] [Pubmed|8626332]References
14652714,16672620,15139916,7883710,7559347,26772920 
