ftsW [2019-08-01 09:06:47]

SEDS family peptidoglycan glycosyltransferase, cell-division protein

Locus: BSU_14850

Isoelectric point: 9.72

Molecular weight: 43.57 kDa

Protein length: 403 aa

Gene length: 1212 bp

Function: cell division

Product: SEDS family peptidoglycan glycosyltransferase

Essential: yes

Synonyms: ylaO

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell division → Other genes
• Groups of genes → Essential genes
• Groups of genes → Membrane proteins

Gene

Coordinates: 1,552,899 1,554,110

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• principal peptidoglycan glycosyltransferase of the divisome PubMed

Protein family

• SEDS proteins (shape, elongation, division, and sporulation) PubMed
• SEDS family (with RodA and SpoVE, according to UniProt)

Paralogous protein(s)

• RodA, SpoVE

Structure

• 6BAR (from Thermus thermophilus,corresponds to aa 97... 359 34% identity) PubMed

Localization

• integral membrane protein
• localizes to the division site PubMed
• localization depends on FtsZ PubMed

Expression and Regulation

Operons

• Genes: ftsW-pycA
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • YofA: activation, PubMed, in YofA regulon
  • stringent response: positive regulation, due to presence of adenines at +1 and +2 positions of the transcript PubMed, in stringent response
  • TnrA: repression, in TnrA regulon

  Regulation

  • constitutively expressed PubMed

Biological materials

Mutant

• MGNA-A563 (ftsW::erm), available at the NBRP B. subtilis, Japan

FLAG-tag construct

• GP2007 ftsW-3xFLAG ermC (based on pGP1087), available in Jörg Stülke's lab

References

Reviews

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Original Publications

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