SubtiBank SubtiBank
sufS [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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sufS [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

cysteine desulfurase, cysteine:SufU sulfuryl transferase
locus
BSU32690
pI
5.00
mw
44.00 kDa
function
formation of iron-sulfur clusters in proteins
product
cysteine desulfurase
essential
yes
ec
2.8.1.7
synonyms
yurW, csd

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.3|Biosynthesis of iron-sulfur clusters]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|iron metabolism], [SW|essential genes]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,357,444 -> 3,358,664

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • terminal phenotype of a CRISPRi knockdown mutant is moderate bulging [Pubmed|27238023]
  • The protein

    Catalyzed reaction/ biological activity

  • transfer of iron to [protein|search|SufU] [Pubmed|21236255]
  • Protein family

  • Csd subfamily (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|NifS], [protein|search|YrvO], [protein|search|NifZ], [protein|search|YcbU]
  • [SW|Cofactors]

  • pyridoxalphosphate [Pubmed|25447671]
  • Effectors of protein activity

  • interaction with [protein|search|SufU] enhances the activity of [protein|search|SufS] 40-fold [Pubmed|20097860]
  • Structure

  • [PDB|5J8Q] [Pubmed|27382962]
  • [SW|Interactions]

  • [SW|SufS]-[SW|SufS], forms homodimers [Pubmed|27382962]
  • [protein|search|SufS]-[protein|search|SufU] [Pubmed|20097860,21236255]
  • [SW|Fra]-[SW|SufS] [Pubmed|27382962]
  • Expression and Regulation

    Operon

  • ''[protein|search|sufC]-[protein|search|sufD]-[protein|search|sufS]-[protein|search|sufU]-[protein|search|sufB]'' [Pubmed|22383849]
  • Biological materials

    Mutant

  • BEC32690, a CRISPRi knockdown mutant of ''[protein|search|sufU]'', is available from the [http://bgsc.org/ Bacillus Genetic Stock Center]
  • References

    Reviews

  • 25447671
  • Original publications

  • 21236255,20097860,20822158,22383849,24321018,15379559,27382962,27238023