ytpQ

unknown

locus: BSU_29830

pI: 5.30

mw: 30.89 kDa

protein length: 269 aa

gene length: 810 bp

function: maybe involved in iron homeostasis

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

Gene

Coordinates: 3,053,364 3,054,173

Phenotypes of a mutant

• derepression of the [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur] and [protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR] regulons [Pubmed|21949854]
• elevated oxidative protein damage upon exposure of the cells to methylglyoxal [Pubmed|21949854]
• the ''[gene|2C6386E9A63F410558D168798D077DF91590F454|spx] [gene|886EF2F8A9E031FDF919E01A858C1DBC1AFF1188|ytpQ]'' doulbe mutant shows reduced growth in minimal medium and hypersensitivity to methylglyoxal [Pubmed|21949854]

The protein

Protein family

• UPF0354 family (single member, according to UniProt)

Expression and Regulation

Operons

• genes: [gene|314D5C01B4BDDC3B122F6D4066647B143B2A6543|ytpP]-[gene|886EF2F8A9E031FDF919E01A858C1DBC1AFF1188|ytpQ]-[gene|EE559CD606562097F09DC627F431CA31129D7BC6|ytpR]
  description: [Pubmed|21949854]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|21949854], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]: activation, [Pubmed|21949854], in [regulon|2C6386E9A63F410558D168798D077DF91590F454|Spx regulon]

Biological materials

Mutant

• MGNA-A437 (ytpQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/437 NBRP B. subtilis, Japan]
• BKE29830 ([gene|886EF2F8A9E031FDF919E01A858C1DBC1AFF1188|ytpQ]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE29830 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTCAAACCGATGTCCT, downstream forward: _UP4_AAGGATTAGAAAGGATTTTT
• BKK29830 ([gene|886EF2F8A9E031FDF919E01A858C1DBC1AFF1188|ytpQ]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK29830 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTCAAACCGATGTCCT, downstream forward: _UP4_AAGGATTAGAAAGGATTTTT

References

• 21949854