pbpH [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

class B penicillin-binding protein H, required for cell wall synthesis during cell elongation

locus: BSU13980

pI: 8.00

mw: 76.00 kDa

function: formation of a rod-shaped peptidoglycan cell wall

product: penicillin-binding protein H

essential: no

synonyms: ykuA

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.7|Penicillin-binding proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|cell wall synthesis], [SW|membrane proteins], [SW|penicillin-binding proteins]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,467,805 -> 1,469,862

The protein

Catalyzed reaction/ biological activity

• required for [SW|cell wall synthesis] during cell elongation [Pubmed|12896990]
• driver of [protein|search|MreB] dynamics [Pubmed|21636744,21636745]

Protein family

• transpeptidase family (according to Swiss-Prot)

[SW|Localization]

• cell membrane (according to Swiss-Prot)
• localization depends on the availability of peptidoglyan precursors (lipid II) [Pubmed|23895585]

[SW|Interactions]

• part of the [SW|elongasome] [Pubmed|21636744,21636745]

Expression and Regulation

Regulatory mechanism

• [protein|search|AbrB]: transcription repression [Pubmed|20817675]

Additional information

• A [protein|search|ncRNA] is predicted between '[protein|search|ykwD]' and '[protein|search|pbpH]' [PubMed|20525796]

References

• 12896990,20525796,21636744,21636745,20817675,23199363,23895585