intramembrane metalloprotease, processing of pro-sigma-K to active SigK
function
processing of pro-sigma-K to active SigK
product
intramembrane metalloprotease
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.3|Proteolysis during sporulation/ germination][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|sigma factors and their control], [SW|proteolysis], [SW|sporulation proteins], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigE regulon]Gene
Coordinates on the chromosome (coding sequence)
2,855,973 -> 2,856,839
The protein
Catalyzed reaction/ biological activity
processing of pro-sigma-K to active [protein|search|SigK] [Pubmed|19805276]Protein family
peptidase M50B family (according to Swiss-Prot)[SW|Domains]
C-terminal cystathionine-beta-synthase (CBS) domain, this domain binds ATP [Pubmed|19805276]Effectors of protein activity
ATP regulates substrate access to the active site and renders cleavage sensitive to the cellular energy level [Pubmed|19805276][SW|Localization]
integral membrane protein [Pubmed|11959848]mother cell membrane [Pubmed|24243021][SW|Interactions]
[SW|SpoIVFB]-pro[protein|search|SigK] [Pubmed|23995631,23585539,19805276][SW|SpoIVFB]-[protein|search|BofA], to inhibit proteolytic activity of [SW|SpoIVFB] [Pubmed|15087499][SW|SpoIVFB]-[SW|SpoIVFA], to facilitate the recruitment of [protein|search|BofA] to [SW|SpoIVFB] [Pubmed|11959848]Expression and Regulation
Operon
''[SW|spoIVFA]-[SW|spoIVFB]'' [Pubmed|1942049]''[SW|spoIVFA]-[SW|spoIVFB]-[protein|search|rplU]-[protein|search|prp]-[protein|search|rpmA]'' [Pubmed|22383849][SW|Sigma factor]
[protein|search|SigE] [Pubmed|15699190,1942049]Regulation
expressed early during sporulation in the mother cell ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|15699190,1942049,15383836]Regulatory mechanism
[SW|SpoIIID]: transcription repression [Pubmed|15383836]References
Reviews
20836086,23479438,19189971,24099006 Original Publications
11959848,9501233,12940997,1577688,12060714,9078383,1942049,10611287,15383836,16818230,19805276,15699190,23585539,23995631,15087499,24243021,22383849 
