SubtiBank SubtiBank
spoIVFB [Fri Mar 11 2016 17:32:39 GMT+0100 (CET)]
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spoIVFB [Fri Mar 11 2016 17:32:39 GMT+0100 (CET)]

intramembrane metalloprotease, processing of pro-sigma-K to active SigK
locus
BSU27970
pI
8.00
mw
33.00 kDa
function
processing of pro-sigma-K to active SigK
product
intramembrane metalloprotease
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.3|Proteolysis during sporulation/ germination]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|sigma factors and their control], [SW|proteolysis], [SW|sporulation proteins], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigE regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,855,973 -> 2,856,839

    The protein

    Catalyzed reaction/ biological activity

  • processing of pro-sigma-K to active [protein|search|SigK] [Pubmed|19805276]
  • Protein family

  • peptidase M50B family (according to Swiss-Prot)
  • [SW|Domains]

  • C-terminal cystathionine-beta-synthase (CBS) domain, this domain binds ATP [Pubmed|19805276]
  • Effectors of protein activity

  • ATP regulates substrate access to the active site and renders cleavage sensitive to the cellular energy level [Pubmed|19805276]
  • [SW|Localization]

  • integral membrane protein [Pubmed|11959848]
  • mother cell membrane [Pubmed|24243021]
  • [SW|Interactions]

  • [SW|SpoIVFB]-pro[protein|search|SigK] [Pubmed|23995631,23585539,19805276]
  • [SW|SpoIVFB]-[protein|search|BofA], to inhibit proteolytic activity of [SW|SpoIVFB] [Pubmed|15087499]
  • [SW|SpoIVFB]-[SW|SpoIVFA], to facilitate the recruitment of [protein|search|BofA] to [SW|SpoIVFB] [Pubmed|11959848]
  • Expression and Regulation

    Operon

  • ''[SW|spoIVFA]-[SW|spoIVFB]'' [Pubmed|1942049]
  • ''[SW|spoIVFA]-[SW|spoIVFB]-[protein|search|rplU]-[protein|search|prp]-[protein|search|rpmA]'' [Pubmed|22383849]
  • [SW|Sigma factor]

  • [protein|search|SigE] [Pubmed|15699190,1942049]
  • Regulation

  • expressed early during sporulation in the mother cell ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|15699190,1942049,15383836]
  • Regulatory mechanism

  • [SW|SpoIIID]: transcription repression [Pubmed|15383836]
  • References

    Reviews

  • 20836086,23479438,19189971,24099006
  • Original Publications

  • 11959848,9501233,12940997,1577688,12060714,9078383,1942049,10611287,15383836,16818230,19805276,15699190,23585539,23995631,15087499,24243021,22383849