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thiO [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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thiO [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

FAD-dependent glycine oxidase
locus
BSU11670
pI
5.90
mw
40.00 kDa
function
biosynthesis of thiamine
product
glycine oxidase
essential
no
ec
1.4.3.19
synonyms
goxB, yjbR
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • This gene is a member of the following [SW|regulons]

  • [SW|Thi-box]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,243,735 -> 1,244,844

    The protein

    Catalyzed reaction/ biological activity

  • Glycine + H2O + O2 = glyoxylate + NH3 + H2O2 (according to Swiss-Prot)

    • Protein family

  • DAMOX/DASOX family (according to Swiss-Prot)

    • Modification

  • FAD [Pubmed|19751796]

    • Structure

  • [PDB|1NG3] (complex with acetyl-glycine), [PDB|1RYI]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • [SW|Interactions]

  • the FAD-containing holoenzyme is a homotetramer [Pubmed|19751796]

    • Expression and Regulation

    Operon

  • ''[protein|search|tenA]-[protein|search|tenI]-[protein|search|thiO]-[protein|search|thiS]-[protein|search|thiG]-[protein|search|thiF]-[protein|search|thiD]'' [Pubmed|1898926]

    • Regulation

  • repressed by thiamine ([protein|search|Thi-box]) [Pubmed|16356850]

    • Regulatory mechanism

  • [protein|search|Thi-box]: [SW|RNA switch] [Pubmed|16356850]

    • References

    Reviews

  • 19348578,10382260

    • Original publications

  • 19254749,11744710,12654003,9827558,12627963,15105420,19751796,19864430,14567704,20690620,24925096