D-alanine carrier protein, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides
function
biosynthesis of teichoic acid
product
D-alanine carrier protein
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)]This gene is a member of the following [SW|regulons]
[SW|SigD regulon], [SW|SigM regulon], [SW|SigX regulon], [SW|Spo0A regulon], [SW|stringent response], [SW|YvrHb regulon]Gene
Coordinates on the chromosome (coding sequence)
3,954,987 -> 3,955,223
Phenotypes of a mutant
more sensitive to nisin [Pubmed|23980836]The protein
Catalyzed reaction/ biological activity
ATP D-alanine poly(ribitol phosphate) = AMP diphosphate O-D-alanyl-poly(ribitol phosphate) (according to Swiss-Prot) Structure
[PDB|4BPG] [Pubmed|26193422]Expression and Regulation
Operon
''[protein|search|dltA]-[protein|search|dltB]-[protein|search|dltC]-[protein|search|dltD]-[protein|search|dltE]'' [Pubmed|7797557][SW|Sigma factor]
[protein|search|SigD] [Pubmed|7797557], [protein|search|SigM] [Pubmed|18179421], [protein|search|SigX] [Pubmed|14762009]Regulation
[protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|7797557]expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]Regulatory mechanism
activated by [SW|YvrHb] [Pubmed|16306698][SW|Spo0A]: transcription repression [Pubmed|7797557]References
Reviews
Original publications
14762009,15955059,26193422,7797557,23980836,21856855,21926231,11434765 
