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dltC
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dltC

D-alanine carrier protein, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides
locus
BSU_38520
pI
3.62
mw
8.87 kDa
protein length
78 aa Sequence Blast
gene length
237 bp Sequence Blast
function
biosynthesis of teichoic acid
product
D-alanine carrier protein
essential
no
ec
6.1.1.13
synonyms
ipa-3r
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]

    • Gene

    Coordinates
    3,954,987 3,955,223

    Phenotypes of a mutant

  • more sensitive to nisin [Pubmed|23980836]

    • The protein

    Protein family

  • DltC family (single member, according to UniProt)

    • [SW|Domains]

  • [SW|Carrier domain] (aa 1-78) (according to UniProt)

    • Modification

  • modified with the 4-phosphopantetheine (Ppant) group at Ser35, by [protein|200BE4802FCE3C860565B374EAADC9C1FEEF3E49|AcpS] [pubmed|30283133], then further modified with a d-alanyl group by [protein|795CD64B65D7CBF26E5F706C7617196CC6FCF864|DltA], through a thioester bond [pubmed|30283133]

    • Structure

  • [PDB|4BPG] [Pubmed|26193422]

    • [SW|Localization]

  • cytoplasm (according to UniProt)

    • Biological materials

    Mutant

  • BKE38520 ([gene|862D977CF1E185597329A1EF0915485F72482A03|dltC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE38520 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAAATCCATAGCTTTCTAAT, downstream forward: _UP4_AATCAGCTGTCTGAGTTGAA
  • BKK38520 ([gene|862D977CF1E185597329A1EF0915485F72482A03|dltC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK38520 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAAATCCATAGCTTTCTAAT, downstream forward: _UP4_AATCAGCTGTCTGAGTTGAA

    • References

    Reviews

  • 24819367

    • Original publications

  • 14762009,15955059,26193422,7797557,23980836,21856855,21926231,11434765,30283133