cortex morphogenic protein A, checkpoint protein, orchestrates spore coat and cortex morphogenesis
function
represses cortex assembly until the successful initiation of spore coat assembly
product
cortex morphogenic protein A, adapter protein targeting SpoIVA for degradation by ClpXP upon spore envelope defects
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.8|Not yet assigned][SW|Categories] containing this gene/protein
[SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|SigE regulon], [SW|SpoIIID regulon]Gene
Coordinates on the chromosome (coding sequence)
525,021 -> 528,076
Phenotypes of a mutant
quicker progressing through the [SW|sporulation ] cycle [Pubmed|22463703]overexpression of CmpA results in heat-sensitive sporulation [Pubmed|22463703,26387458], this can be suppressed by mutations in ''[SW|clpP]'' and ''[SW|clpX]'' [Pubmed|26387458]Protein
Catalyzed reaction/ biological activity
orchestrates spore coat and cortex assembly [Pubmed|22463703]represses cortex assembly until spore coat assembly successfully initiates [Pubmed|22463703][SW|Localization]
surface of the developing spore, this depends on a functional [SW|SpoIVA] [Pubmed|22463703,26387458][SW|Interactions]
[SW|ClpX]-[SW|CmpA] (for [SW|ClpX]-[SW|ClpP]-dependent degradation of [SW|SpoIVA]) [Pubmed|26387458][SW|CmpA]-[SW|SpoIVA] (for [SW|ClpX]-[SW|ClpP]-dependent degradation of [SW|SpoIVA]) [Pubmed|26387458]Expression and Regulation
Operon
''[SW|cmpA] '' [Pubmed|22463703,20709900]Sigma factor
[SW|SigE] [Pubmed|22463703]Regulation
expressed in mother cell during [SW|sporulation ] ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|22463703]Regulatory mechanism
[SW|SpoIIID]: transcription activation [Pubmed|22463703]References
Original publications
22463703,26387458,20709900 
