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ctpB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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ctpB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

carboxy-terminal processing serine protease, cleaves SpoIVFA, this results in processing of pro-SigK
locus
BSU35240
pI
8.64
mw
52.00 kDa
function
control of SigK activation
product
carboxy-terminal processing serine protease,
cleaves SpoIVFA
essential
no
synonyms
yvjB

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.4|Additional proteins involved in proteolysis]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [SW|Categories] containing this gene/protein

  • [SW|proteolysis], [SW|sigma factors and their control], [SW|sporulation proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigE regulon], [SW|SigG regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,622,356 -> 3,623,798

    The protein

    Protein family

  • PDZ protease [Pubmed|24243021]
  • Paralogous protein(s)

  • [protein|search|CtpA]
  • Effectors of protein activity

  • substrate binding of CtpB induces opening of the PDZ gate and protease activation [Pubmed|24243021]
  • [protein|search|CtpB] acts in concert with a second signaling protease, [SW|SpoIVB] [Pubmed|24243021]
  • Structure

  • [PDB|4C2C] [Pubmed|24243021]
  • forms a ring-like scaffold with two narrow tunnels for substrate binding [Pubmed|24243021]
  • [SW|Localization]

  • intracellular space between the mother cell and the forespore [Pubmed|24243021]
  • [SW|Interactions]

  • forms a dimeric ring [Pubmed|24243021]
  • [protein|search|CtpB]-[SW|SpoIVFA] [Pubmed|24243021]
  • Expression and Regulation

    Operon

  • ''ctpB'' (according to [http://dbtbs.hgc.jp/COG/prom/ctpB.html DBTBS])
  • [SW|Sigma factor]

  • [protein|search|SigE] [Pubmed|15699190], [protein|search|SigG] [Pubmed|15699190,16497325]
  • Regulation

  • expressed during sporulation ([protein|search|SigE], [protein|search|SigG]) [Pubmed|15699190,16497325]
  • Biological materials

    Mutant

  • 1S129 ( ''ctpB''::''tet''), [Pubmed|14526016], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S129&Search=1S129 BGSC]
  • References

  • 14526016,17557826,16818230,15699190,16497325,24243021