SubtiBank SubtiBank
fhuD [Mon Aug 31 2015 13:56:47 GMT+0200 (CEST)]
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fhuD [Mon Aug 31 2015 13:56:47 GMT+0200 (CEST)]

hydroxamate siderophore ABC transporter (only ferrichrome) (binding protein)
locus
BSU33320
pI
9.16
mw
34.00 kDa
function
siderophore uptake
product
hydroxamate siderophore ABC transporter
(only ferrichrome) (binding protein)
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|acquisition of iron], [SW|iron metabolism]
  • This gene is a member of the following [SW|regulons]

  • [SW|Fur regulon]
  • Gene

    Phenotypes of a mutant

  • poor growth with the xenosiderophore ferrichrome as single source of iron [Pubmed|23220087]
  • The protein

    Protein family

  • bacterial solute-binding protein 8 family (according to Swiss-Prot)
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot), extracellular (signal peptide) [Pubmed|18957862]
  • [SW|Interactions]

  • [protein|search|FhuC]-([protein|search|FhuB]-[protein|search|FhuG])-([protein|search|FhuD]-[protein|search|YxeB]) [Pubmed|10092453]
  • Expression and Regulation

    Operon

  • ''fhuD'' (according to [http://dbtbs.hgc.jp/COG/prom/fhuD.html DBTBS])
  • Regulation

  • induced upon iron starvation ([protein|search|Fur]) [Pubmed|12354229]
  • Regulatory mechanism

  • [protein|search|Fur]: transcription repression [Pubmed|12354229]
  • References

  • 10092453,16672620,12354229,18957862,23220087