sknR

transcriptional repressor ([SW|Xre family]) of the [gene|16BEDCFFB1671793061ACE4AC528D3B8EB177DC8|yqaF]-[gene|02216407B5EDB98FAF611E22B2323C819B9D58BB|yqdA]-[gene|03DAF537379754763646AF3AF2AD811B107F5302|yqaG]-[gene|F6AB74740776179E77218DB831FEE03773B7353F|yqaH]-[gene|5EA0F507F949D249D5B5B860861BBEB4197E01C5|yqaI]-[gene|CFCCFD8C6420CC1DD076B091AD3D914FC8AB22D5|yqaJ]-[gene|903E11BD2CFF3EE1A831F0F50F91741893C3DAB8|yqaK]-[gene|AB4AF9BD3E16FD72370AFC82CDD1531518053E6F|yqaL]-[gene|F301EA8201BF27BAFAD4F95EC3A580A91B970B06|yqaM]-[gene|3A89444BA25E4940C4197AACBD8B66BC1C65A493|yqaN] operon of the [SW|skin element]

locus: BSU_26350

pI: 5.42

mw: 13.17 kDa

protein length: 116 aa

gene length: 351 bp

function: control of prophage gene expression

product: transcriptional repressor ([SW|Xre family])

essential: yes

synonyms: yqaE

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
• [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.3|Skin element]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 2,698,893 2,699,243

Phenotypes of a mutant

• essential in the wild type background (due to overexpression of the toxic proteins [protein|F6AB74740776179E77218DB831FEE03773B7353F|YqaH] and [protein|F301EA8201BF27BAFAD4F95EC3A580A91B970B06|YqaM]) [Pubmed|20889742]
• no phenotype if deleted with the complete [SW|skin element] [Pubmed|20889742]

The protein

Catalyzed reaction/ biological activity

• binds the yqaF promoter region to repress transcription of the ''[gene|16BEDCFFB1671793061ACE4AC528D3B8EB177DC8|yqaF]-[gene|02216407B5EDB98FAF611E22B2323C819B9D58BB|yqdA]-[gene|03DAF537379754763646AF3AF2AD811B107F5302|yqaG]-[gene|F6AB74740776179E77218DB831FEE03773B7353F|yqaH]-[gene|5EA0F507F949D249D5B5B860861BBEB4197E01C5|yqaI]-[gene|CFCCFD8C6420CC1DD076B091AD3D914FC8AB22D5|yqaJ]-[gene|903E11BD2CFF3EE1A831F0F50F91741893C3DAB8|yqaK]-[gene|AB4AF9BD3E16FD72370AFC82CDD1531518053E6F|yqaL]-[gene|F301EA8201BF27BAFAD4F95EC3A580A91B970B06|yqaM]-[gene|A9AACF8F25A1A80B3AE2A94DFC3A0E09012B55E7|yqzO]-[gene|3A89444BA25E4940C4197AACBD8B66BC1C65A493|yqaN]'' operon [Pubmed|20889742]

Protein family

• [SW|Xre family]

Paralogous protein(s)

• [protein|71012848B12CB7BCDEEACDAC6AD1966A971F8FAB|YonR], [protein|25F494F32E200FC0FE4C81A05B0F70CB449673EA|Xre]

[SW|Domains]

• [SW|HTH cro/C1-type domain] (aa 6-60) (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|846161AE54F170075F2B2133A8D56FE39A5AF8D9|sknR]
  description: [Pubmed|22383849]

References

• 20889742