gpsA [2017-8-11 16:0:3]

glycerol-3-phosphate dehydrogenase (NAD)

locus: BSU22830

pI: 6.23

mw: 37.28 kDa

protein length: 345 aa

gene length: 1035 bp

function: biosynthesis of phospholipids

product: glycerol-3-phosphate dehydrogenase (NAD)

essential: no

ec: 1.1.1.94

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.5|Other proteins required for biofilm formation]

Gene

Coordinates: 2,389,151 → 2,390,188

Phenotypes of a mutant

• essential [Pubmed|12682299], non-essential according to [Pubmed|28189581]

The protein

Catalyzed reaction/ biological activity

• sn-glycerol 3-phosphate + NAD(P)⁺ = glycerone phosphate + NAD(P)H (according to Swiss-Prot)

Protein family

• NAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot)

Structure

• [PDB|3K96] (from ''Coxiella burnetii RSA 493'', 37% identity, 59% similarity)

[SW|Localization]

• cytoplasm [Pubmed|15743965]

Expression and Regulation

Operons

• genes: [gene|B2270316642C66BC2DA86EBDCD1BF6A33CC6A1DC|yphC]-[gene|8440C1DBE485BB9EF2904FAA5D709A574C3819A4|gpsA]
  description: [pubmed|22383849]

• genes: [gene|5DA8B27AC6A0E0B4115512BD948C31964D387A8E|yphA]-[gene|448375DF74EB0482A6CD1ACFE04D117C1319E2B2|seaA]-[gene|910109496E4A41EC892996DEEB81971FCBD9CB05|ypzH]-[gene|B2270316642C66BC2DA86EBDCD1BF6A33CC6A1DC|yphC]-[gene|8440C1DBE485BB9EF2904FAA5D709A574C3819A4|gpsA]
  description: [pubmed|22383849]

References

• 7592341,15743965,28189581