SubtiBank SubtiBank
gpsA
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gpsA

glycerol-3-phosphate dehydrogenase (NAD)
locus
BSU22830
pI
6.23
mw
37.28 kDa
protein length
345 aa Sequence Blast
gene length
1035 bp Sequence Blast
function
biosynthesis of phospholipids
product
glycerol-3-phosphate dehydrogenase (NAD)
essential
no
ec
1.1.1.94
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    2,389,151 → 2,390,188

    Phenotypes of a mutant

  • essential [Pubmed|12682299], non-essential according to [Pubmed|28189581]
  • The protein

    Catalyzed reaction/ biological activity

  • sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H (according to Swiss-Prot)
  • Protein family

  • NAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot)
  • Structure

  • [PDB|3K96] (from ''Coxiella burnetii RSA 493'', 37% identity, 59% similarity)
  • [SW|Localization]

  • cytoplasm [Pubmed|15743965]
  • Expression and Regulation

    Operons

    genes
    [gene|B2270316642C66BC2DA86EBDCD1BF6A33CC6A1DC|yphC]-[gene|8440C1DBE485BB9EF2904FAA5D709A574C3819A4|gpsA]
    description
    [pubmed|22383849]
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    Biological materials

    Mutant

  • BKE22830 (Δ[gene|8440C1DBE485BB9EF2904FAA5D709A574C3819A4|gpsA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE22830 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCATGTTTGATTCACACC, downstream forward: _UP4_TAAAAGTGTCAATCAAATGG
  • BKK22830 (Δ[gene|8440C1DBE485BB9EF2904FAA5D709A574C3819A4|gpsA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK22830 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCATGTTTGATTCACACC, downstream forward: _UP4_TAAAAGTGTCAATCAAATGG
  • References

  • 7592341,15743965,28189581