SubtiBank SubtiBank
serS
The papers of the month are back! Check them out! Link here

serS

seryl-tRNA-synthetase
locus
BSU00130
pI
5.19
mw
48.68 kDa
protein length
425 aa Sequence Blast
gene length
1275 bp Sequence Blast
function
translation
product
seryl-tRNA-synthetase
essential
yes
ec
6.1.1.11
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    20,880 → 22,157

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser) (according to Swiss-Prot)
  • Protein family

  • Type-1 seryl-tRNA synthetase subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|1SES] (from ''Thermus thermophilus'', 36% identity, 56% similarity) [Pubmed|8128224]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    genes
    [gene|82B92D2FB8DB88689D3A8B77FAD2F63FCCA04C7E|serS]
    description
    [Pubmed|8915527]

    regulatory mechanism

  • [regulon|T-box|T-box]: anti-termination, in [regulon|T-box|T-box]
  • regulation

  • induced by serine limitation ([protein|search|T-box]) [Pubmed|19258532]
  • view in new tab

    genes
    [gene|7C3081BC8D416127A881627EB56C0628359111CF|dacA]-[gene|651D1E534490276B9BE7BFE7B5819176AE09891E|pdxS]-[gene|6F96C10759C1C20B3A6B396E3718F0A9281F100A|pdxT]-[gene|82B92D2FB8DB88689D3A8B77FAD2F63FCCA04C7E|serS]
    description
    [Pubmed|22383849]

    regulation

  • the leader mRNA is processed upstream of [gene|7C3081BC8D416127A881627EB56C0628359111CF|dacA] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|YmcA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|YlbF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|YaaT] complex [Pubmed|29794222]
  • Additional information

  • [protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP]∼P binds to the promoter region, but regulation has not been explored [pubmed|25666134]
  • view in new tab

    genes
    [gene|651D1E534490276B9BE7BFE7B5819176AE09891E|pdxS]-[gene|6F96C10759C1C20B3A6B396E3718F0A9281F100A|pdxT]-[gene|82B92D2FB8DB88689D3A8B77FAD2F63FCCA04C7E|serS]
    description
    [Pubmed|22383849]
    view in new tab

    References

  • 19258532,8915527